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KMID : 0363620110320060041
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Journal of Korean Oriental Medicine
2011 Volume.32 No. 6 p.41 ~ p.53
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Effect of Jaeumgeonbigagamtang (JGT) on Restraint-induced Oxidative Stress in Mouse Brain
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Yun Jung-Hun
An Joung-Jo
Jo Hyun-Kyung
Son Chang-Gue
Kim Yoon-Sik
Seol In-Chan
Yoo Ho-Rhyong
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Abstract
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Objectives: This study was performed to investigate the effect of Jaeumgeonbigagamtang (JGT) onrestraint-induced oxidative stress in the mouse brain.
Methods: After treatment with JGT, CBC, ROS, MDA, TAC, SOD, activity of catalase, and total GSH content were analyzed.
Results: JGT had a strong antioxidant activity by in vitro assay as presented GEAC. JGT treatment significantly ameliorated decrease of blood WBC and increase of platelet count. JGT (50mg/kg) treatment significantly ameliorated increase of MDA and GSH content level in brain tissue. JGT (100mg/kg) treatment significantly ameliorated increase of MDA and activity of TAC level in brain tissue. JGT (200mg/kg) treatment significantly ameliorated increase of ROS, MDA, activity of TAC level and depletion of catalase level in brain tissue.
Conclusion: The present study demonstrated antioxidant activity in brain tissue. This result would be consistent with the long clinical efficacy of JGT, and this finding may provide a strong possibility of JGT as a drug candidate for brain-specific multiple disorders and symptoms.
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KEYWORD
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Jaeungeonbigagamtang (JGT), oxidative stress, antioxidant activity, malondialdehyde (MDA)
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